Ravala, SK, Adame-Garcia, SR, Li, S, Chen, C, Cianfrocco, MA, Gutkind, SJ, Cash, Jennifer*, Tesmer, JJG*. (2023) Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4. bioRxiv, DOI: 10.1101/2023.09.15.557836 *co-corresponding authors
Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1. J Biol Chem, 298, 102209. DOI: 10.1016/j.jbc.2022.102209
Lu, T., Aoto, P., Weng, J., Nielsen, C, Cash, Jennifer, Hall, J., Zhang, P., Simon, S., Cianfrocco, M., Taylor, S. (2020) Structural analyses of the PKA RIIß holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma. PLoS Biology, 18, e3001018. DOI: 10.1371/journal.pbio.3001018
Cash, Jennifer, Kearns, S., Li, Y., and Cianfrocco, M. (2020) High-Resolution Cryo-EM Using Beam-Image Shift at 200 keV. International Union of Crystallography Journal, 7, 1179-1187. DOI: 10.1107/S2052252520013482
Ravala, S., Hopkins, J., Plescia, C., Allgood, S., Kane, M., Cash, Jennifer, Stahelin, R., Tesmer, J. (2020) The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding. Journal of Biological Chemistry, 295, 12635-12647. DOI: 10.1074/jbc.RA120.014534
Li, Y., Cash, Jennifer, Tesmer, J., and Cianfrocco, M. (2020) High-Throughput Cryo-EM Enabled by User-Free Preprocessing Routines. Structure, 28, 1-12. DOI: 10.1016/j.str.2020.03.008
Cash, Jennifer, Chandan, N., Sharma, P., Smrcka, A., and Tesmer, J. (2020) Discovery of Small Molecules that Target the P-Rex1 PIP3-binding Site and Inhibit P-Rex1-dependent Functions in Human Neutrophils. Molecular Pharmacology, 97, 226-236. DOI: 10.1124/mol.119.117556
Cash, Jennifer, Urata, S., Li, S., Ravala, S., Avramova, L., Shost, M., Gutkind, J., Tesmer, J., and Cianfrocco, M. (2019) Cryo-electron Microscopy Structure and Analysis of the P-Rex1–Gbg signaling scaffold. Science Advances 5, eaax8855. DOI: 10.1126/sciadv.aax8855
Cash, Jennifer, Sharma, P., and Tesmer, J. (2019) Structural and Biochemical Characterization of the Pleckstrin Homology Domain of the RhoGEF P-Rex2 and Its Regulation by PIP3. Journal of Structural Biology: X 1, 100001. DOI: 10.1016/j.yjsbx.2018.100001
Cash, Jennifer, Davis, E., and Tesmer, J. (2016) Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure 24, 730-740. DOI: 10.1016/j.str.2016.02.022
Cash, Jennifer, Angerman, E., Kirby, R., Merck, L., Seibel, W., Wortman, M., Papoian, R., Nelson, S., and Thompson, T. (2013) Development of a Small Molecule Screening Method for Inhibitors of Cellular Response to Myostatin and Activin A. Journal of Biomolecular Screening 18, 837-844. DOI: 10.1177/1087057113482585
Cash, Jennifer, Angerman, E., Keutmann, H., and Thompson, T. (2012) Characterization of Follistatin-Type Domains and Their Contribution to Myostatin and Activin A Antagonism. Molecular Endocrinology 26, 1167-1178. DOI: 10.1210/me.2012-1061
Cash, Jennifer, Angerman, E., Kattamuri, C., Nolan, K., Zhao, H., Sidis, Y., Keutmann, H., and Thompson, T. (2011) The Structure of Myostatin:Follistatin-like 3: N-terminal Domains of Follistatin-type Molecules Exhibit Alternate Modes of Binding. JBC 287, 1043-1053. DOI: 10.1074/jbc.M111.270801
Cash, Jennifer, Rejon, A., McPherron, A., Bernard, D., and Thompson, T. (2009) The Structure of Myostatin:Follistatin 288: Insights into Receptor Utilization and Heparin Binding. EMBO J 28, 2662-2676. DOI: 10.1038/emboj.2009.205
Cash, Jennifer, Korchnak, A., Gorman, J., Tandon, Y., and Fraizer, G. (2007) VEGF transcription and mRNA stability are altered by WT1 not DDS(R384W) expression in LNCaP cells. Oncology Reports 17, 1413-1419. DOI: 10.3892/or.17.6.1413
Hanson, J., Reese, J., Gorman, J., Cash, Jennifer, Fraizer, G. (2007) Hormone treatment enhances WT1 activation of Renilla luciferase constructs in LNCaP cells. Frontiers in Bioscience 12, 1387-1394. DOI: 10.2741/2155
